A Cese of Colorectal Cancer which was Safely Treated with Folfiri, Although Complicated by Reversible Posterior Leukoencephalopathy Syndrome after Bevacizumab + FOLFOX

Reversible posterior leukoencephalopathy syndrome after bevacizumab/FOLFIRI regimen for metastatic colon cancer.

OBJECTIVE To describe a patient with reversible posterior leukoencephalopathy syndrome following the administration of bevacizumab (Avastin), a monoclonal antibody against vascular endothelial growth factor. DESIGN Case report/literature review. SETTING University hospital. PATIENT A 52-year-old man receiving chemotherapy for stage IV rectal carcinoma. RESULTS Clinical and radiographic ...

Posterior reversible leukoencephalopathy syndrome after kratom ingestion.

Posterior reversible encephalopathy syndrome has been associated with hypertension, preeclampsia, cancer chemotherapy, and drugs of abuse, such as amphetamine and methamphetamine. We report a young man who suddenly developed severe headache, disorientation, and aphasia following ingestion of kratom and Adderall. Computed tomography and magnetic resonance imaging of his head revealed foci of vas...

Reversible posterior leukoencephalopathy syndrome after carboplatin therapy.

A 53-year-old woman presented in September 2004 with a stage IV adenocarcinoma in the upper lobe of the left lung with pleuropulmonary metastasis. She was treated with cisplatin (70 mg/m 2 on day 1 and gemcitabine 1250 mg/m 2 on days 1 and 8) by intravenous administration every 3 weeks. After five treatment cycles, the administration of cisplatin was stopped because of a low clearance creatinin...

Reversible posterior leukoencephalopathy syndrome.

Reversible Posterior Leukoencephalopathy Syndrome

Hinchey et al used the term „reversible posterior leukoencephalopathy syndrome“ in 1996 to describe a syndrome characterized by headache, confusion, seizures and vision disturbances, including cortical blindness, connected with reversible changes on brain magnetic resonance imaging (MRI) which pointed to the white matter eodema, predominantly in the posterior brain regions (1). Initially, this ...